Are you looking for all Fallout 76 Brain Fungus Locations, so you can complete challenges to earn easy rewards? You can gather 5 Brain Fungus for 250 S.C.O.R.E. daily or collect 25 to score 1,000 S.C.O.R.E. weekly. If you’re looking to knock out those challenges fast, your best option is Fallout 76 Wendigo Cave, backed by several strong secondary locations across Appalachia. Here’s where to go and how many you’ll find.
Where to Find Brain Fungus Fallout 76
The most common Brain Fungus locations in Fallout 76 are most commonly found in the Cranberry Bog and the southern part of The Mire, often growing inside underground areas or along tunnel systems. The best place to farm Brain Fungus in Fallout 76 is Wendigo Cave, which offers more than enough to complete both your daily and weekly S.C.O.R.E. challenges. If Wendigo Cave has already been picked over on your server, these are the next best locations to farm Brain Fungus, ranked by yield:
| Location | Approximate Count | Notes / Tips |
|---|---|---|
| Wendigo Cave | ~100 | Located in the Savage Divide, this is the top spot in the game. Expect tight corridors and high enemy density. |
| Kerwood Mine | ~57 | Spawns are well spread throughout the mine. |
| Big Bend Tunnel East & West (side tunnels) | ~52 total | Focus on rough-dug side tunnels rather than the main path. |
| Carleton Mine | ~40 | Straightforward underground spot. |
| Tunnel under State Route 65 (Bog Town to Watoga) | ~30 | Look for hidden tunnel entrances off the highway. |
| Abandoned Waste Dump | ~28 | Five are on the ceiling—use Marsupial or a jet pack. |
| Uncanny Caverns | ~29 | Dense with spawns across cave sections. |
| Gauley Mine | ~26 | Easy to clear and efficient. |
| Fort Defiance | ~20 | Scattered through lower levels. |
| Atlas Substructure | ~19 | Compact area with clustered spawns. |
| Whitespring Service Entrance | ~15 | Found near dumpsters in the service zone. |
| Emmett Mountain Disposal Site | ~15 | In the small cave connecting generator and storage rooms. |
| Carson Family Bunker | 7 | Tucked into bunker corridors. |
| The Deep | ~7 | Located in pre-Motherlode cave sections. |
| Rusty Pick | 7 | Two near the restrooms, five deeper inside. |
| Enclave Research Facility | 4 | Check the containment areas. |
| Angler Pond (far northeast) | 3 | On rock walls around the water. |
| Kill Box | 3 | Two are found on the stairs to the third floor. |
| Dried Riverbed at the Lost Home | 3 | Lower riverbed sections. |
| House near Vault 63 | 2 | Inside or near the entrance. |
| Reverend Delbert Winters’ Trailer | 2 | Inside the trailer in Flatwoods. |
| Raleigh Clay’s Bunker | 2 | Spawns are inside the bunker. |
| Kanawha Nuka-Cola Plant | 2 | Check the basement level. |
| Horizon’s Rest | 1 | Inside the downed airplane. |
| Hornwright Summer Villa | 1 | In the basement. |
| Groves Family Cabin | 1 | On a bunkbed. |
| Helvetia Church | 1 | Underneath the Mothman altar. |
| Mole Miners’ Camp (unmarked, near Palace of the Winding Path) | 1 | On a rock wall just south of the palace. |
Why Wendigo Cave Is the Best Option & How to Use It
- Wendigo Cave is located in the Savage Divide region of Appalachia. It’s a medium‑size dungeon with claustrophobic corridors and multiple chambers.
- Because it hosts high spawn density (~100 in estimates), it outpaces nearly every other site in raw yield.
- When you go, bring movement tools (Marsupial, jet pack) or careful vertical traversal gear, since some spawns are on ceilings or high ledges.
- Also, because it’s a more “major dungeon” type location, you’ll encounter enemy density—so come prepared.
Tips for Efficient Brain Fungus Farming
- Server hop to refresh Brain Fungus spawns
- Use the Marsupial mutation or jet pack to reach hard-to-access ceilings
- Prioritize Wendigo Cave to complete daily or weekly challenges quickly
- Be ready for enemies—Wendigo Cave and other top locations are packed with hostile creatures
- Explore side paths and vertical spaces—many spawns are tucked away
Outro
While you’re clearing out the Wendigo Cave, make sure to finish the Cripple a Mirelurk’s Limb challenge for another easy 250 S.C.O.R.E. For even more daily challenge tips, farming routes, and collectibles, head over to our Fallout 76 Hub to stay ahead in Appalachia.
